26/04/2026
In a newly published, peer-reviewed study, our Research & Development team compared to an extract prepared from Host Defense® Lion’s Mane (Hericium erinaceus) mushroom mycelium and a commercially available fruiting body extract, analyzing differences in bioactive-compound profiles and biological activity on immune cells in-vitro. Rather than focusing on a single molecule, the study examined how the whole fungal system behaves—including beta-glucan structure and immune-modulating signaling pathways.
Using transcriptomic and protein-level analyses, the research identified distinct biological responses associated with Lion’s Mane mushroom mycelium compared to fruiting body extracts—underscoring the importance of fungal tissue type and preparation.
These findings reinforce a key concept in the field of mycology: different growth stages of the same species can express distinct characteristics. Studying cultivated mushroom mycelium under controlled conditions allows researchers to isolate, repeat, and better understand these differences with consistency.
Learn how mushroom mycelium differs from common fruiting body extracts, and why preparation matters when it comes to immune and cellular resilience.*
Read the press release: https://bit.ly/3Z362E8
*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
